Drug Mechanism Theory

Today, we are gonna learn short topic about Drug Mechanism Theory.
Basically, rhere are three types of drug mechanism theory. ehic are;

1. Occupancy theory
2. spare receptor theory
3. Rate Theory.

Occupancy Theory

The occupancy theory follw law mass-action. Where state that the magnitude of response is directly proportional to the number of receptor occupied . Based on the occupancy  theory, the maximal response will be achieved when all the receptor has been fully filled with ligand. 

Spare receptor theory

This theory is very simple, where it state that it is not necessary to all of the receptor to be filled to achieved thje maximal respon. The maximal respon can be create even only one of those receptors fill.

Rate Theory 

In order to achieve the maximal response, it is depend on the rate of receptor to be filled with the ligand. It menas that, the more ligand-receptor interaction occur per unit time, the stronger the response create.

okay, that's all for today, maybe inthe next post i'll go to other topic in Pathology section.

Best Regards.

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Basic Concept Of Pharmacokinetic

Basically, there are two main component in pharmacology study. Which are pharmacokinetics and pharmacodynamics.

 Pharmacokinetics talk about the drug movement into , within and out of the body. Whereas pharmacodynamics talk about what does the drug do to body.

Okay, today, we will focus into pharmacokinetics. Pharmacokinetics involve four main steps. Which are absorption, distribution, metabolism and excretion. Mnemonically as ADME.

Absorption is about the transfer of drugs from site of administration to the systemic circulation. Distribution about the transfer of drugs from systemic circualtion to tissues. And metabolism is a process of biotransformation of drugs. And lastly, excretion will do the remove task inside our body. Excretion will removes drugs from the body whether by renal or hepatobilliary system.

So, that all, the very basic things about pharmacokinetic. In next post, i will go more detail into all of these steps.

Best regards.

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Synthesis And Metabolism Of Noradrenaline

Noradrenaline is a type of neurotransmitter inside our body. It helps us to bring sympahtetic repon to our body such as dilation of pupil, bronchodilation, and lipolysis.

There are five processes of synthesis and metabolism of noradrenaline(NA) which are synthesis, storange of NA, release of NA, receptor binding , and termination.

Synthesis of NA involve several steps that involve the changing of tyrosine to NA. It is start with Tyrosine will convert to dopa by enzyme tyrosine hydroxylase. Then DOPA will convert to Dopamine by dopa decarboxylase. After that dopamine will convert to NA by dopamine-beta-hydroxylase.

Settle with the synthesis. Then ,Storage of NA. Dopamine will be transport to the vesicle. After the storage of NA in vesicle, the NA will be release to synapses by exocytosis with help of Calcium ion.

Then, NA will bind to protein at the post-synaptic tissue known as adrenergic receptor. 

The last step will be Termination of NA. There are four ways NA will be terminate which are by uptake 1, uptake 2, diffusion, and enzyme reaction.

Okay, that's all for today. in the next post, i will share about some of the enzyme that will inhibit those processes that i mention about.

Best regards,

myeducationalnotes

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